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Medchemexpress LLC Ethanone, 1-[5-[(2,4-difluorophenyl)thio]-4-nitro-2-thienyl]- | 1247819-59-5 | 98.4% | 315.32 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY13865

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P 22077 is a cell-permeable ubiquitin-specific protease 7 (USP7) inhibitor that also inhibits USP47. It demonstrates antiproliferative activity against human HCT116 cells and reduces the viability of neuroblastoma cells. The compound increases p53 activity, induces apoptosis in p53 wild-type and HDM2-expressing neuroblastoma cells, and enhances the cytotoxic effects of Dox and VP-16. In vivo, it exhibits potent antitumor activities in xenograft mouse models.

  • Cell-permeable ubiquitin-specific protease 7 (USP7) inhibitor
  • Inhibits USP47
  • Exhibits antiproliferative activity against human HCT116 cells
  • Reduces cell viability of neuroblastoma cells
  • Increases p53 activity and induces apoptosis in p53 wild-type cells
  • Enhances cytotoxic effect of Dox and VP-16 on neuroblastoma cells
  • Shows potent antitumor activities in xenograft mouse models

Catalog No. 50-003-49179


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