Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000349179

Medchemexpress LLC Ethanone, 1-[5-[(2,4-difluorophenyl)thio]-4-nitro-2-thienyl]- | 1247819-59-5 | 98.4% | 315.32 | 25 MG
SDP

Catalog No. 5000349179
Encompass_Preferred

P 22077 is a cell-permeable ubiquitin-specific protease 7 (USP7) inhibitor that also inhibits USP47. It demonstrates antiproliferative activity against human HCT116 cells and reduces the viability of neuroblastoma cells. The compound increases p53 activity, induces apoptosis in p53 wild-type and HDM2-expressing neuroblastoma cells, and enhances the cytotoxic effects of Dox and VP-16. In vivo, it exhibits potent antitumor activities in xenograft mouse models.

  • Cell-permeable ubiquitin-specific protease 7 (USP7) inhibitor
  • Inhibits USP47
  • Exhibits antiproliferative activity against human HCT116 cells
  • Reduces cell viability of neuroblastoma cells
  • Increases p53 activity and induces apoptosis in p53 wild-type cells
  • Enhances cytotoxic effect of Dox and VP-16 on neuroblastoma cells
  • Shows potent antitumor activities in xenograft mouse models

Catalog No. 50-003-49179 Supplier Medchemexpress LLC Supplier No. 25MGHY13865
May include imposed supplier surcharges.
Add to Cart
Add to Cart

missing translation for 'validMainframeMsg'

P 22077 is a cell-permeable ubiquitin-specific protease 7 (USP7) inhibitor that also inhibits USP47. It demonstrates antiproliferative activity against human HCT116 cells and reduces the viability of neuroblastoma cells. The compound increases p53 activity, induces apoptosis in p53 wild-type and HDM2-expressing neuroblastoma cells, and enhances the cytotoxic effects of Dox and VP-16. In vivo, it exhibits potent antitumor activities in xenograft mouse models.

  • Cell-permeable ubiquitin-specific protease 7 (USP7) inhibitor
  • Inhibits USP47
  • Exhibits antiproliferative activity against human HCT116 cells
  • Reduces cell viability of neuroblastoma cells
  • Increases p53 activity and induces apoptosis in p53 wild-type cells
  • Enhances cytotoxic effect of Dox and VP-16 on neuroblastoma cells
  • Shows potent antitumor activities in xenograft mouse models

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.