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Medchemexpress LLC Ethyl 3-hydroxybutyrate | 5405-41-4 | 99.99% | 132.16 | 50 G
Supplier: Medchemexpress LLC HYW01270150G
Ethyl 3-hydroxybutyrate is a fragrance found in wine and *Tribolium castaneum*. In vivo, Ethyl 3-hydroxybutyrate (300 mg/kg, ip, once daily for 28 days) increases 3-HB levels in serum, promotes TCA cycle and protein synthesis, improves metabolic homeostasis. Ethyl 3-hydroxybutyrate reduces inflammation responses and enhances antioxidant capacity, and alleviates cancer cachexia-associated skeletal muscle atrophy in CT26 xenograft mouse models.
- Increased the levels of 3-HB in serum and gastrocnemius muscle.
- Reduced weight loss, skeletal muscle atrophy, tumor weight.
- Improved mice survival.
- Reduced levels of IFN-γ and TGF-β in serum.
- Improved the structure of gastrocnemius muscle, partially restored the cross-sectional area of muscle fibers.
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