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Medchemexpress LLC Ethyl (4bS,8R,8aS,14bR)-7-(cyclopropylmethyl)-...-12-carboxylate | 892039-23-5 | 99.4% | C29H30N2O5 | 10MG
SDP

Supplier:  Medchemexpress LLC HY13620810MG

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TAN-452 is an orally active, selective peripherally acting δ-opioid receptor (DOR) antagonist derived from naltrindole. It displays high potency at DOR (Ki 0.47 nM; Kb 0.21 nM), shows low brain penetrability, and can attenuate morphine-induced side effects without significantly reducing analgesia. The compound also exhibits antagonist activity at μ- and κ-opioid receptors at higher concentrations.

  • Selective peripheral DOR antagonist with subnanomolar potency.
  • Low brain penetrability reduces central nervous system exposure.
  • Attenuates morphine-induced side effects while preserving analgesia.
  • Also antagonizes μ- and κ-opioid receptors at higher concentrations.
  • White to off-white solid supplied with high reported purity.

Catalog No. 50-002-61939


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