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Cell Signaling Technology Etoposide, Topoisomerase II Inhibitor, >98% Purity, 5.9 mg
SDP

Catalog No. NC1608114
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Etoposide (VP-16) is an anti-tumor agent that functions as a topoisomerase II inhibitor. It stabilizes the covalent topoisomerase II-cleaved DNA intermediate complex, leading to genomic instability and cell death, and is commonly used as an apoptosis inducer. This chemical modulator is supplied as a lyophilized powder.

  • IC50: 59.2 μM
  • Purity: >98%
  • Mechanism of action: Stabilizes covalent topoisomerase II-cleaved DNA intermediate complex, delaying cell cycle progression through late S and early G2 phases
  • Reconstitution: For a 25 mM stock solution, reconstitute the 5.9 mg in 400 μL DMSO
  • Solubility: 25 mg/mL in DMSO
  • Typical usage: 5–50 μM for 4–24 hr treatments
  • Storage: Store lyophilized or in solution at -20°C, desiccated

Catalog No. NC1608114 Supplier Cell Signaling Technology Supplier No. 2200S
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Etoposide (VP-16) is an anti-tumor agent that functions as a topoisomerase II inhibitor. It stabilizes the covalent topoisomerase II-cleaved DNA intermediate complex, leading to genomic instability and cell death, and is commonly used as an apoptosis inducer. This chemical modulator is supplied as a lyophilized powder.

  • IC50: 59.2 μM
  • Purity: >98%
  • Mechanism of action: Stabilizes covalent topoisomerase II-cleaved DNA intermediate complex, delaying cell cycle progression through late S and early G2 phases
  • Reconstitution: For a 25 mM stock solution, reconstitute the 5.9 mg in 400 μL DMSO
  • Solubility: 25 mg/mL in DMSO
  • Typical usage: 5–50 μM for 4–24 hr treatments
  • Storage: Store lyophilized or in solution at -20°C, desiccated

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