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Apexbio Technology LLC Evacetrapib (LY2484595) 1186486-62-3 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A43775.1
Evacetrapib (LY2484595 CAS 1186486-62-3) is a potent and selective inhibitor targeting cholesteryl ester transfer protein (CETP) a regulator of lipid metabolism Evacetrapib exhibits inhibitory activity with IC50 values of 5 5 nM in assays containing recombinant human CETP and 26 nM within human plasma CETP assays In vivo oral administration at 30 mg/kg in human CETP/ApoAI double-transgenic mice significantly reduces CETP activity and elevates HDL-cholesterol concentration (ED50 5 mg/kg) Evacetrapib does not elevate blood pressure nor induce aldosterone or cortisol synthesis in model systems highlighting its potential in cardiovascular research related to coronary artery disease
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