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Medchemexpress LLC Evixapodlin | 2374856-75-2 | 98.1% | 691.61 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY13840750MG

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Evixapodlin (GS-4224) is a human PD-1/PD-L1 protein/protein interaction inhibitor with an IC50 of 0.213 nM. It exhibits anticancer and antiviral functions.

  • Enhances IFN-γ and Granzyme B production in chronic hepatitis B (CHB) CD8+ T cells and CD4+ T cells.
  • Increases the frequency of GrB+ cells among HBV-specific CD8+ and CD4+ T cells.
  • In vivo treatment shows >90% PD-L1 target occupancy on tumor cells.
  • Significantly inhibits tumor growth in a human PD-L1 expressing MC38 mouse colorectal tumor model.

Catalog No. 50-003-48898


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