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Apexbio Technology LLC EX 527 (SEN0014196) 49843-98-3 25mg
Supplier: Apexbio Technology LLC A418125
EX 527 (SEN0014196 CAS 49843-98-3) is a small-molecule inhibitor targeting the catalytic activity of the SIRT1 enzyme By selectively inhibiting SIRT1 EX 527 increases acetylation of the tumor suppressor protein p53 following DNA damage Research using etoposide-treated cells indicates that inhibition by EX 527 does not significantly alter cellular viability growth or p53-regulated gene transcription EX 527 demonstrates high selectivity for SIRT1 showing approximately 200 500-fold greater specificity compared to homologous enzymes SIR2 and SIRT3 Additionally EX 527 exists as a racemic mixture separable into distinct stereoisomers (EX-242 EX-243) via chiral HPLC aiding structure-activity studies
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