EX 527

Description

CAS: 49843-98-3 | C13H13ClN2O | 248.71 g/mol

EX-527 is a potent and selective sirtuin 1 (SIRT1) inhibitor (IC50 38 nM) identified from a high throughput screen. EX-527 is more selective (200-500-fold) for SIRT1 than for SIRT2 or SIRT3 and has been shown to be a potent SIRT6 inhibitor using H3K56 deacetylation site based substrate. EX-527 does not inhibit class I/II HDAC activity at concentrations up to 100uM. Enhances p53 acetylation in response to DNA damaging agents. EX-527 is racemic; the active isomer (EX-243) gives similar results and potency whereas the other isomer (designated EX-242) is inactive.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
EX-527 is a potent and selective sirtuin 1 (SIRT1) inhibitor (IC50 38 nM) identified from a high throughput screen. EX-527 is more selective (200-500-fold) for SIRT1 than for SIRT2 or SIRT3 and has been shown to be a potent SIRT6 in

Specifications

Chemical Identifiers

• CAS: 49843-98-3
• Molecular Formula: C13H13ClN2O
• Molecular Weight (g/mol): 248.71
• MDL Number: MFCD03009471
• InChI Key: FUZYTVDVLBBXDL-UHFFFAOYSA-N
• Synonym: selisistat, sirt1 inhibitor iii, 1h-carbazole-1-carboxamide, 6-chloro-2,3,4,9-tetrahydro, 6-chloro-2,3,4,9-tetrahydro-1h-carbazole-1-carboxamide, racemic, selisistat inn, 6-chloro-1,2,3,4,9-pentahydro-4ah-carbazolecarboxamide, ex-527 selisistat, ex 527 selisistat, d0e3lp, cambridge id 6859180
• PubChem CID: 5113032
• IUPAC Name: 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
• SMILES: C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N

• Color: White
• Quantity: 10 mg
• Solubility Information: Soluble in dimethyl sulfoxide,ethanol and dimethyl formamide.
• Formula Weight: 248.71
• Physical Form: Powder
• Chemical Name or Material: EX 527

Safety and Handling

Hazard Category	H302-H319
Hazard Statement	GHS H Statement H302-H319 Harmful if swallowed. Causes serious eye irritation.
Precautionary Statement	P264b-P270-P280i-P301+P312-P305+P351+P338-P330-P501c
TSCA	No
Recommended Storage	Keep cold

SDS

RUO – Research Use Only