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Medchemexpress LLC Exatecan mesylate | 169869-90-3 | 101.1% | 531.55 | 50 MG
SDP

Catalog No. 5000350968
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Exatecan mesylate (DX8951f) is a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM (0.975 μg/mL). It is utilized in cancer research.

  • Potent topoisomerase I inhibitor.
  • Inhibits proliferation of several cancer cell lines (mean GI50s 0.877-2.92 ng/mL).
  • Displays cytotoxic activities against PC-6 and PC-6/SN2-5 cells.
  • Stabilizes DNA-TopoI complexes in PC-6 and PC-6/SN2-5 cells.
  • Exhibits antitumor activities in mouse models without toxic death.
  • Highly inhibits MIA-PaCa and BxPC-3 primary tumor growth in early-stage models.
  • Suppresses BxPC-3 lymphatic metastasis and eliminates lung metastasis in late-stage cancer models.

Catalog No. 50-003-50968 Supplier Medchemexpress LLC Supplier No. HY13631A50MG
May include imposed supplier surcharges.
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Exatecan mesylate (DX8951f) is a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM (0.975 μg/mL). It is utilized in cancer research.

  • Potent topoisomerase I inhibitor.
  • Inhibits proliferation of several cancer cell lines (mean GI50s 0.877-2.92 ng/mL).
  • Displays cytotoxic activities against PC-6 and PC-6/SN2-5 cells.
  • Stabilizes DNA-TopoI complexes in PC-6 and PC-6/SN2-5 cells.
  • Exhibits antitumor activities in mouse models without toxic death.
  • Highly inhibits MIA-PaCa and BxPC-3 primary tumor growth in early-stage models.
  • Suppresses BxPC-3 lymphatic metastasis and eliminates lung metastasis in late-stage cancer models.

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