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Cayman Chemical Exatecnmesylate 50mg
Supplier: Cayman Chemical 3545250 MG
A DNA topoisomerase I inhibitor (IC50 = 0.975 UG/ml); inhibits cell growth in a panel of 32 breast, colon, stomach, and lung cancer cell lines (GI50s = 0.125-10.4 ng/ml); reduces tumor growth in an SC-6-JCK gastric adenocarcinoma mouse xenograft model from 3.325-50 mg/kg; reduces tumor weight in HCT116, PC-6, and PC12 mouse xenograft models at 75 mg/kg; has been used in the synthesis of cytotoxic payload moieties of ADCs
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