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Apexbio Technology LLC EZ Cap Human p53 mRNA 5x1mg (1mg/mL)
Supplier: Apexbio Technology LLC R10235
Human p53 mRNA encodes transcription factors P53 It responds to oncogenic signals by activating downstream genes such as the pro-apoptotic protein BAX and up-regulating apoptosis regulators like PUMA Additionally p53 acts as a cell cycle checkpoint protector by inducing cell cycle arrest participating in DNA replication and repair and maintaining genome integrity EZ Cap Human p53 mRNA has a concentration of approximately 1 mg/mL It is synthesized with a Cap 1 structure by co-transcriptional capping The Cap 1 structure is more suitable for mammalian systems and exhibits higher transcriptional efficiency compared to Cap 0 structures (ARCA and mCap) The addition of a Poly(A) tail enhances the stability and lifespan of the mRNA both in vitro and in vivo Furthermore the Poly(A) tail plays a crucial role in improving translation initiation efficiency
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