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Apexbio Technology LLC EZ Cap Mouse CD137 mRNA (m1Ψ HA tag) 1mg (1mg/mL)

Supplier: Apexbio Technology LLC R10771

Mouse CD137 mRNA encodes CD137P(4-1BB) mainly expressed on activated T cells natural killer (NK) cells and dendritic cells The ligand for CD137 is 4-1BBL primarily expressed on antigen-presenting cells Activation of CD137 enhances T-cell proliferation and survival and promotes the secretion of cytokines such as IFN- and IL-2 thereby strengthening immune responses Activating CD137 can enhance anti-tumor immune responses CD137 signaling pathways play complex roles in autoimmune diseases and transplant rejection EZ Cap Mouse CD137 mRNA (m1 HA tag) supplied at 1 mg/mL encodes mouse-derived CD137 cytokine fused to HA tag facilitating subsequent protein expression detection It contains a cap 1 structure generated through co-transcriptional capping Incorporation of modified nucleotides m1 along with a poly (A) tail minimizes RNA-induced innate immune activation and enhances mRNA stability and lifespan both in vitro and in vivo
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