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Apexbio Technology LLC Ezatiostat hydrochloride 286942-97-0 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B12505.1
Ezatiostat hydrochloride (CAS 286942-97-0) also known as TLK199 is a small-molecule inhibitor primarily targeting glutathione S-transferase (GST) specifically the GST P1-1 isoform GST P1-1 typically suppresses the Jun N-terminal kinase (JNK) signaling pathway thus Ezatiostat hydrochloride through GST P1-1 inhibition activates JNK signaling In preclinical research this activation has been associated with increased proliferation maturation and differentiation of hematopoietic precursor cells Additionally Ezatiostat hydrochloride induces growth arrest and apoptosis in human leukemia HL-60 cells (CC50 approximately 6-17 M) It holds potential for treating cytopenias and hematological disorders
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