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Medchemexpress LLC EZM0414 TFA | 2411759-92-5 | 95.5% | 514.51 | 1 MG
Supplier: Medchemexpress LLC HY1363281MG
EZM0414 TFA is the TFA salt form of EZM0414, a potent, selective, and orally active inhibitor of SETD2. It is characterized by an IC50 of 18 nM in the SETD2 biochemical assay and 34 nM in the cellular assay. This compound is suitable for research into relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma.
- Potent, selective, orally active inhibitor of SETD2
- Inhibits proliferation of multiple myeloma and diffuse large B-cell lymphoma cell lines
- Inhibits tumor growth in NOD SCID mouse xenograft models
- Shows robust tumor growth regressions in t(4;14) multiple myeloma cell line-derived xenograft models
- Associated with reductions in intratumoral H3K36me3 levels
- Demonstrates high oral bioavailability in rats and mice
- Well-tolerated in animal studies
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