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Medchemexpress LLC EZM0414 TFA | 2411759-92-5 | >97.2% | 514.51 | 1 ML
Supplier: Medchemexpress LLC HY13632810MM/1ML
EZM0414 TFA, also known as SETD2-IN-1 TFA, is a potent, selective, and orally active inhibitor of SETD2 (IC50=18 nM in biochemical assay; IC50=34 nM in cellular assay). It is used for research into relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma.
- Potent, selective, and orally active SETD2 inhibitor.
- Inhibits proliferation of MM and DLBCL cell lines.
- Shows robust tumor growth regressions in xenograft models.
- Well-tolerated in animal studies.
- Exhibits high oral bioavailability in rats and mice.
- Soluble in DMSO and water for in vitro applications.
- Provides various in vivo solubility protocols for clear solutions.
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