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ABclonal Technology F10 Rabbit pAb
Supplier: ABclonal Technology A14521000UL
This gene encodes vitamin K-dependent coagulation factor X, a key player in the blood coagulation cascade. Factor X is processed into a mature two-chain form, with the light chain containing two EGF-like domains and the heavy chain holding the catalytic domain. It is activated by factor IXa (intrinsic pathway) or factor VIIa (extrinsic pathway) and then converts prothrombin to thrombin during clotting, in the presence of factor Va, Ca+2, and phospholipids. Mutations in this gene cause factor X deficiency, leading to hemorrhagic conditions. Alternative splicing produces multiple transcript variants that may undergo similar processing to generate mature polypeptides.
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