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MORADEC LLC Fab-αHFc-CL-DMDM, 50 μg, Human IgG Fc region specific, Cleavable linker, Alkylates DNA
Supplier: MORADEC LLC AH202DD50
Fab Anti-Human IgG Fc-Duocarmycin DM Antibody with Cleavable Linker is a specialized secondary antibody-drug conjugate designed for research applications. This product uniquely combines the Fab fragment of a polyclonal antibody with Duocarmycin DM, a cytotoxic small molecule, to facilitate targeted cell death through DNA alkylation. The cleavable linker ensures stability in extracellular environments and offers selective activation within cells for enhanced delivery of therapeutic agents. This approach creates opportunities for innovative antibody lead screening in ADC development.
- Target specificity for the human IgG Fc region
- Monovalent nature of the Fab fragment
- Stability in extracellular fluid
- Cleavable linker activated by intracellular cathepsins
- Alkylation mechanism targeting DNA minor groove
- Suitable for antibody pre-screening applications
- 50 μg quantity available
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