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Medchemexpress LLC Farudodstat | 1035688-66-4 | 99.7% | 10 MG
Supplier: Medchemexpress LLC HY12923910MG
Farudodstat is an orally active and potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 35 nM for the human DHODH enzyme. It inhibits protein synthesis by activating AP-1 transcription factors, induces apoptosis, and significantly prolongs survival in acute myeloid leukemia (AML) xenograft mice.
- Potent Dihydroorotate Dehydrogenase (DHODH) inhibitor
- IC50 of 35 nM for human DHODH enzyme
- Inhibits protein synthesis via activation of AP-1 transcription factors
- Induces apoptosis
- Substantially prolongs survival in acute myeloid leukemia (AML) xenograft mice
- Inhibits leukemic cell proliferation
- Increases cleaved caspase 8
- Decreases viability and induces differentiation in primary acute myeloid leukemia blasts and myelodysplastic syndrome samples
- Causes downregulation of EIF4B and RPL6 proteins
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