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Cayman Chemical Faty ACD Free BSA asy R 250uL
SDP

Supplier:  Cayman Chemical 700933250 UL

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A HAT1 inhibitor (IC50 14.8 UM) selective for HAT1 over KAT2A and p300/CBP-associated factor (PCAF) for which it has no activity KAT5 KAT6B and KAT7 (IC50s >100 >100 and 84.82 UM respectively) CBP and p300 (IC50s 90.41 and 74.25 UM respectively) reduces acetylation of H4K5 and H4K12 in hTert-HME1 mammary epithelial cells at 20 UM reduces the growth of HCC1806 and A549 cells (EC50s 10.4 and 1.9 UM respectively) reduces intratumoral H4K12 acetylation in an A549 mouse xenograft model in a dose-dependent manner reduces tumor growth in an A549 mouse xenograft model at 50 and 100 mg/kg once every three days

Catalog No. 50-289-2590


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