Medchemexpress LLC FAUC 213 | 337972-47-1 | 99.9% | C18H19ClN4 | 25 MG

Supplier:  Medchemexpress LLC 25MGHY14327

FAUC 213 is an orally active and highly selective dopamine D4 receptor complete antagonist with a Ki of 2.2 nM for hD4.4. It shows less activity on D2 and D3 receptors (Kis of 3.4 μM and 5.3 μM for hD2 and hD3, respectively). FAUC 213 can cross the blood-brain barrier (BBB) and exhibits atypical antipsychotic characteristics. It is for research use only and not sold to patients.

• Targets hD4.4 receptor (Ki = 2.2 nM), hD2 receptor (Ki = 3.4 μM), hD3 receptor (Ki = 5.3 μM)
• Inhibits p5-HT1 (Ki=1.2 μM), p5-HT2 (Ki=0.52 μM), pα1 (Ki=0.27 μM) in vitro
• Significantly reduces amphetamine-induced locomotor hyperactivity with pre-treatment of 30 mg/kg in vivo
• Significantly restores prepulse inhibition reduction caused by apomorphine treatment with 30 mg/kg in vivo

Catalog No. 50-003-56494