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Medchemexpress LLC FB23 | 2243736-35-6 | 98.9% | 377.22 | 50 MG
Supplier: Medchemexpress LLC HY13718750MG
FB23 is a potent and selective FTO demethylase inhibitor with an IC50 of 60 nM. It directly binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity.
- Potent and selective FTO demethylase inhibitor
- IC50 of 60 nM against FTO
- Directly binds to FTO
- Selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity
- Inhibits proliferation of acute myeloid leukemia (AML) cells (e.g., NB4 and MONOMAC6)
- Suppresses MYC and E2F targets
- Activates apoptosis and p53 pathways
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