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AdipoGen Fc hFLT3 Ligand hrec
Supplier: AdipoGen AG40B01193010
Protein. The receptor-binding domain of human FLT3L aa1-185 is fused at the N-terminus to the Fc portion of human IgG1. Source CHO cells. Endotoxin content <0.1EU/µg purified protein LAL test Lonza. Liquid. In PBS sterile. Binds to human and mouse FLT3 receptor. Purity >95% SDS-PAGE. FMS-like tyrosine kinase 3 ligand FLT3L acts as a growth factor that increases the number of immune cells lymphocytes B cells and T cells by activating the hematopoietic progenitors. It binds to FLT3 CD135 which is found on multipotent progenitor MPP and common lymphoid progenitor CLP cells in mice. FLT3L induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells. FLT3L is crucial for steady-state pDC plasmacytoid dendritic cells and cDC classical dendritic cells development. Deficiency of FLT3L causes a dramatic decrease in DC numbers, whereas increasing its availability increase in DC numbers.
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