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AdipoGen Fc hGrancalcin h rec
Supplier: AdipoGen AG40B0242C050
Recombinant protein. Human Grancalcin aa 1-217 is fused at the N-terminus to the Fc portion of human IgG1. Source HEK 293 cells. Lyophilized. Contains PBS. Grancalcin is a member of a new family of proteins named penta-EF-hand PEF, which contains five repetitive EF hand motifs. PEF proteins form a unique group including calpain, sorcin, grancalcin, ALG-2 apoptosis-linked gene-2 protein and peflin. The penta-EF hand members are Ca2-binding proteins implicated in regulating cell migration, apoptosis and the mobilization of immune cells. Senescent cells accumulate in the bone marrow and secrete factors, termed senescence-associated secretory phenotype SASP, that can promote skeletal aging. Recently, senescent neutrophils and macrophages in the bone marrow were shown to be critical cell types during skeletal aging releasing Grancalcin GCA to promote such aging.
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