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AdipoGen Fc (human):CD137L, Soluble (human) (rec.) (3 x 10 µg)
Supplier: AdipoGen AG40B01733010
Protein. The receptor-binding domain of human CD137L (aa 85-254) is fused at the N-terminus to the Fc portion of human IgG1. Source: HEK 293 cells. Lyophilized. Contains PBS. Purity: >90% (SDS-PAGE). The CD137 ligand (CD137L; 4-1BBL) is a member of the tumor necrosis factor (TNF) family. CD137L is a type II transmembrane protein found on activated macrophages, dendritic cells and mature B cells. The interaction with its receptor 4-1BB induces recruitment of TNF receptor-associated factor 1 (TRAF1) and TRAF2 and interaction with the kinase p56lck. CD137 and CD137L have been reported to be involved in tumor rejection, apoptosis, anti-viral immunity, diabetes and in T and B cell co-stimulation and modulation of the immune response.
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