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AdipoGen Fc humanFNDC4 rec
Supplier: AdipoGen AG40B0213C050
Recombinant Protein. FNDC4 extracellular domain, human aa 45-167 / mouse aa 41-163 is fused at the N-terminus to the Fc portion of human IgG1. FNDC4 extracellular domain has 100% identity between human, mouse, rat, dog and monkey. Lyophilized. Contains PBS. Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin. Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. FNDC4 is an ortholog of FNDC5 with 50% identity and 86% similarity compared to Irisin. FNDC4 as well as FNDC5 are extremely well conserved between species. The human FNDC4 gene is highly enriched in liver, brain tissue and adipocytes.
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