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AdipoGen Fc LALA-PG-KIHhGDF15 ms
Supplier: AdipoGen AG40B0245C050
Recombinant protein. The extracellular domain of mouse GDF15 aa 189-303 is fused to the C-terminus of the Fc LALA-PG Knob region of human IgG1. Fc LALA-PG KnobsGDF15 mouse and Fc LALA-PG Holes form the Fc LALA-PG-KIH humanGDF15 mouse rec. using the Knobs-into-Holes technology see reference J.B. Ridgway, et al. Protein Eng. 9, 617 1996. Source HEK 293 cells. Produced using animal component-free medium. Lyophilized. Contains PBS Binds to its receptor GDNF family receptor alpha-like GFRALmouse with a ED50 < 5ng /ml. Growth and differentiation factor 15 GDF15, also known as macrophage inhibitory cytokine-1 MIC-1, is a member of the transforming growth factor TGF-beta superfamily and was initially identified in activated macrophages. GDF15 acts through a recently identified receptor called Glial-derived Neurotrophic Factor GDNF Receptor Alpha-Like GFRAL which signals through the Rearranged during Transfection RET tyrosine kinase receptor.
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