Medchemexpress LLC FD-IN-1 | 1646682-14-5 | 98.6% | 10 MG

Supplier:  Medchemexpress LLC HY12857010MG

FD-IN-1 is an orally bioavailable and selective factor D (FD) inhibitor with an IC50 of 12 nM. This compound targets the alternative complement pathway of the innate immune system, and also exhibits inhibitory activity against factor XIa (FXIa) and Tryptase β2.

• Selective factor D inhibitor (IC50 of 12 nM)
• Inhibits factor XIa (FXIa) and Tryptase β2
• Exhibits high oral bioavailability (83% in mice, 70% in dogs)
• Demonstrates systemic and local ocular suppression of AP activation
• Terminal elimination half-lives of 1.6 hours in mice and 3.8 hours in dogs
• Fully inhibits AP pathway for up to 10 hours at 10 mg/kg dose in human FD knock-in mice
• Molecular weight of 377.43 and chemical formula C23H23NO4
• Appears as a white to off-white solid

Catalog No. 50-003-42559