Medchemexpress LLC Febrifugine dihydrochloride | 32434-42-7 | 1 MG

Supplier:  Medchemexpress LLC HYN2384A1MG

Febrifugine dihydrochloride is a quinazolinone alkaloid with antimalarial activity against *P. falciparum*. It also shows anticancer properties in bladder cancer by inhibiting DNA synthesis, inducing apoptosis, and reducing steroids, leading to G1 phase increase and G2 phase decrease in cancer cells. Its action involves suppressing DNA synthesis and promoting apoptosis via downregulating key steroidogenesis factors.

• Inhibits *P. falciparum*.
• Possesses antimalarial activity.
• Inhibits bladder cancer cell proliferation.
• Induces apoptosis in bladder cancer cells.
• Reduces steroid synthesis in bladder cancer cells.
• Increases eIF2α phosphorylation in *P. falciparum*.
• Increases G1 phase cells and decreases G2 phase cells in bladder cancer.
• Significantly reduces mortality and parasitemia in an animal model of malaria.
• Effectively inhibits bladder cancer xenograft proliferation in mice.

Catalog No. 50-004-20400