Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC Fedratinib (hydrochloride hydrate) | 1374744-69-0 | 99.9% | 615.62 | 1 G
Supplier: Medchemexpress LLC 1GHY10409A
Fedratinib hydrochloride hydrate is a potent, selective, ATP-competitive, and orally active inhibitor of JAK2. It exhibits an IC50 of 3 nM for both JAK2 and JAK2V617F kinase and demonstrates significant selectivity over JAK1 (35-fold) and JAK3 (334-fold). This compound has been shown to induce apoptosis in cancer cells and is considered to have potential for research in myeloproliferative disorders.
- Potent, selective, ATP-competitive, and orally active JAK2 inhibitor.
- Targets both JAK2 and JAK2V617F kinase effectively at 3 nM IC50.
- Exhibits high selectivity against JAK1 (35-fold) and JAK3 (334-fold).
- Induces apoptosis in cancer cells.
- Shows promise for research in myeloproliferative disorders.
- Inhibits proliferation of cell lines carrying the JAK2V617F mutation.
- Reduces STAT5 phosphorylation.
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?