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Medchemexpress LLC FEN1-IN-4 | 1995893-58-7 | 99.9% | 232.24 | 1 MG
SDP

Catalog No. 5000349378
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FEN1-IN-4 is a human flap endonuclease-1 (hFEN1) inhibitor. It is for research use only. FEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a. FEN1 is a potential chemosensitizing target due to its role in LP-BER, which is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines.

  • Human flap endonuclease-1 (hFEN1) inhibitor
  • Selectively impairs proliferation of colon cancer cells
  • Potential chemosensitizing target in LP-BER
  • Increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines

Catalog No. 50-003-49378 Supplier Medchemexpress LLC Supplier No. HY1364851MG
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FEN1-IN-4 is a human flap endonuclease-1 (hFEN1) inhibitor. It is for research use only. FEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a. FEN1 is a potential chemosensitizing target due to its role in LP-BER, which is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines.

  • Human flap endonuclease-1 (hFEN1) inhibitor
  • Selectively impairs proliferation of colon cancer cells
  • Potential chemosensitizing target in LP-BER
  • Increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines

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