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Cayman Chemical FenbrutInIb 10mg
SDP

Supplier:  Cayman Chemical 2134610 MG

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A BTK inhibitor (Kis = 0.91, 1.6, 1.3, 12.6, and 3.4 nM for wild-type BTK, BTKC481S, BTKC481R, BTKT474I, and BTKT474M, respectively); selective for BTK over a panel of 287 additional kinases at 1 µM; inhibits anti-IgM antibody-induced BTK phosphorylation in B cells (IC50 = 3.1 nM), as well as anti-IgM- or CD40L-induced proliferation of B cells (IC50s = 1.2 and 1.4 nM, respectively); reduces ankle thickness and cartilage damage in a rat model of collagen-induced arthritis

Catalog No. 50-298-5032


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