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Cayman Chemical Fenobamhydrate 10mg
Supplier: Cayman Chemical 2975910 MG
A noncompetitive antagonist and inverse agonist of mGluR5 that binds to an allosteric site; inhibits quisqualate-induced intracellular calcium mobilization in HEK293 cells expressing the human receptor (IC50 = 58 nM); inhibits basal activity of mGluR5 in a cell-based assay (IC50 = 84 nM); reduces stress-induced hyperthermia in mice at 10 and 30 mg/kg; increases drinking time in the Vogel conflict test in rats at 30 mg/kg; induces analgesia in the formalin test in mice at 30 mg/kg
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