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Medchemexpress LLC Fenofibric acid | 42017-89-0 | 99.9% | 500 MG
Supplier: Medchemexpress LLC HYB0760R500MG
Fenofibric acid is an active metabolite of fenofibrate and a PPAR activator, showing EC50s of 22.4 μM for PPARα, 1.47 μM for PPARγ, and 1.06 μM for PPARδ. It also inhibits COX-2 enzyme activity with an IC50 of 48 nM. This product is for research use only.
- Potently activates PPARα, PPARγ, and PPARδ
- Inhibits COX-2 enzyme activity
- Shows anti-inflammatory activity in Wistar rats
- Reduces abundance of AOX1 protein in HepG2 cells
- Decreases JNK1/2, c-Jun, and p38 MAPK phosphorylation
- Prevents accumulation of reactive oxygen species, ER stress, and disruption of the blood retinal barrier
- Activates IGF-IR/Akt/ERK1/2-mediated survival signaling pathways
- High purity of 99.94%
- Available in various forms: solid and solution in DMSO
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