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Cayman Chemical FENRETINIDE 100MG
SDP

Catalog No. 502980038
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An inhibitor of dihydroceramide desaturase (IC50 = 2.32 µM); promotes the generation of ROS, degradation of MCL-1, and cleavage of PKCδ; selectively activates RARγ at 5-20 µM; inhibits the growth of Caov-3, OVCAR-3, and SKOV3 ovarian cancer cells (IC50s = 3.7, 6.9, and 8.2 µM, respectively); increases activity of SPT by 1.75-fold and induces caspase-dependent apoptosis in BMEC cells (IC50 = 2.4 µM); prevents lipid-induced reductions in insulin-stimulated glucose uptake in isolated rat soleus muscle; reduces liver and soleus muscle neutral lipid content and inhibits high-fat diet-induced increases in dihydroceramide desaturase transcription at 10 mg/ml

Catalog No. 50-298-0038 Supplier Cayman Chemical Supplier No. 17688100 MG
May include imposed supplier surcharges.
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An inhibitor of dihydroceramide desaturase (IC50 = 2.32 µM); promotes the generation of ROS, degradation of MCL-1, and cleavage of PKCδ; selectively activates RARγ at 5-20 µM; inhibits the growth of Caov-3, OVCAR-3, and SKOV3 ovarian cancer cells (IC50s = 3.7, 6.9, and 8.2 µM, respectively); increases activity of SPT by 1.75-fold and induces caspase-dependent apoptosis in BMEC cells (IC50 = 2.4 µM); prevents lipid-induced reductions in insulin-stimulated glucose uptake in isolated rat soleus muscle; reduces liver and soleus muscle neutral lipid content and inhibits high-fat diet-induced increases in dihydroceramide desaturase transcription at 10 mg/ml

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