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Medchemexpress LLC Ferroptosis-IN-21 (8-hydroxy-1,2,3,4-tetrahydroquinoline) | 6640-50-2 | 149.19 | 25 G
SDP

Catalog No. 5000449547
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Ferroptosis-IN-21 is a ferroptosis inhibitor that protects against renal ischemia/reperfusion (I/R) injury. It acts by suppressing ferroptosis and directly scavenging peroxyl radicals, exhibiting broad-spectrum anti-ferroptotic efficacy and nanomolar potency in renal tubular epithelial cells.

  • Exhibits nanomolar cytoprotective activity (EC50 = 61.7 nM) and reverses cell death
  • Protects human kidney cells from induced ferroptosis
  • Suppresses lipid Reactive Oxygen Species accumulation
  • Demonstrates potent direct radical scavenging activity
  • Ameliorates renal I/R injury in mice
  • Reduces serum creatinine and blood urea nitrogen in I/R models
  • Decreases lipid peroxidation biomarkers
  • Useful for ferroptosis-targeted drug development research

Catalog No. 50-004-49547 Supplier Medchemexpress LLC Supplier No. 25GHYW002942
May include imposed supplier surcharges.
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Ferroptosis-IN-21 is a ferroptosis inhibitor that protects against renal ischemia/reperfusion (I/R) injury. It acts by suppressing ferroptosis and directly scavenging peroxyl radicals, exhibiting broad-spectrum anti-ferroptotic efficacy and nanomolar potency in renal tubular epithelial cells.

  • Exhibits nanomolar cytoprotective activity (EC50 = 61.7 nM) and reverses cell death
  • Protects human kidney cells from induced ferroptosis
  • Suppresses lipid Reactive Oxygen Species accumulation
  • Demonstrates potent direct radical scavenging activity
  • Ameliorates renal I/R injury in mice
  • Reduces serum creatinine and blood urea nitrogen in I/R models
  • Decreases lipid peroxidation biomarkers
  • Useful for ferroptosis-targeted drug development research

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