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Apexbio Technology LLC Ferrostatin-1 (Fer-1) 347174-05-4 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A43715.1
Ferrostatin-1 (Fer-1) is a selective inhibitor of ferroptosis a regulated form of iron-dependent oxidative cell death characterized by lipid peroxidation It functions primarily by reducing lipid reactive oxygen species (ROS) thus inhibiting membrane lipid peroxidation and preventing ferroptosis induction triggered by compounds such as erastin In experimental contexts Fer-1 is employed to investigate ferroptotic pathways in different disease models including cancer biology neurodegeneration and ischemic injury Ferrostatin-1 demonstrates an IC50 value of approximately 60 nM in inhibiting ferroptosis induced by erastin in cellular assays rendering it suitable for mechanistic studies and therapeutic research involving modulation of iron-dependent oxidative damage pathways
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