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Genscript Corporation Antibody Protein Proteins Proteins 10 UG 1/EA

Supplier:  Genscript Corporation Z0310010

Encompass

Fibroblast Growth Factor 18 (FGF-18) is a pleiotropic cytokine belonging to the heparin-binding FGF family which has 23 different members. Structurally FGF-18 is closely related to FGF-8 and FGF-17. Like other FGFs FGF-18 can bind to different FGF receptors in vivo. FGF-18 is expressed in various tissues and has multiple functions: during long bone growth FGF-18 is expressed in perichondrium and developing joints and regulates bone formation by inhibiting chondrocyte proliferation and differentiation; FGF-18 knock-out mice survive embryonic development but exhibit skeletal abnormalities and die in the early neonatal period. FGF-18 also induces ectopic cartilage formation in the lung and alters the morphology of the pulmonary mesenchyma.

Catalog No. 50-252-9843


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