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AdipoGen FGF-23 hFc h rec
Supplier: AdipoGen AG40A0109C050
Protein. Signal peptide and human FGF-23 aa 1-251 are fused at the C-terminus to the Fc portion of human IgG1. Source HEK 293 cells. Endotoxin content <0.1EU/µg purified protein LAL test Lonza. Liquid. 0.2µm-filtered solution in PBS. Purity >90% SDS-PAGE. FGF-23 Fibroblast growth factor 23 is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets ADHR and of hyperphosphatemic familial tumoral calcinosis HFTC.
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