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AdipoGen FGF-23 mouseFc h rec
Supplier: AdipoGen AG40A0128YC010
Recombinant protein. Mouse FGF-23 aa25-251 is fused at the C-terminus to the Fc portion of human IgG1. Activates ERK and FRS2alpha phosphorylation in Klotho expressing cells. Source/Host HEK 293 cells. Purity >90% SDS-PAGE. Lyophilized. Contains PBS. FGF-23 Fibroblast growth factor 23 is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets ADHR and of hyperphosphatemic familial tumoral calcinosis HFTC.
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