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Genscript Corporation Antibody Protein Proteins Proteins 1 MG 1/EA
Supplier: Genscript Corporation Z031641
Fibroblast Growth Factor-6 (FGF-6) is a cytokine belonging to the heparin-binding FGF family and is structurally related to other members of FGF family particularly FGF-4. In vivo FGF-6 exhibits an expression profile predominantly restricted tothe myogenic lineage and it preferentially binds to two of the FGF receptors: FGFR1 and FGFR4. FGF-6 functions in muscle regeneration myoblast proliferation and migration and muscle differentiation in a dose-dependent manner. In vivo high concentration of recombinant FGF-6 up-regulates and down-regulates FGFR1 and FGFR4 respectively as FGFR1 promotes the proliferation while FGFR4 promotes the differentiation in the muscle. Besides its dual function in muscle regeneration FGF-6 may act as a regulator of bone metabolism as well.
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