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Genscript Corporation Antibody Protein Proteins Proteins 10 UG 1/EA
Supplier: Genscript Corporation Z0329910
Fibroblast Growth Factor 8e (FGF-8e) is a cytokine belonging to the heparin-binding FGF family which has at least 23 members. FGF-8 has 8 different isoforms named FGF-8a through FGF-8h. Different FGF-8 isoforms have different receptor affinities and thus participate in different signaling cascade pathways. FGF-8 has widespread expression during embryonic development promoting gastrulation somitogenesis morphogenesis and limb formation. FGF-8 also has oncogenic potential. While in normal cells FGF-8 is expressed at very low levels in breast prostate and ovarian cancer FGF-8 is highly expressed.FGF-8 promotes tumor angiogenesis by increasing neovascularization and inducing osteoblastic differentiation.
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