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Genscript Corporation Antibody Protein Proteins Proteins 50 UG 1/EA
Supplier: Genscript Corporation Z0304950
Fibroblast Growth Factor- acidic (FGF-acidic) is a mitogen targeting at the endothelial cells and belongs to the heparin binding FGF family which contains 22 members. FGF-acidic binds to the receptor family FGFR1-4 in vivo with the assistance of heparin. However along with FGF -basic FGF-acidic lacks the signal peptide segment and thus is not secreted via endoplasmic reticulum (ER) and Golgi bodies. Studies have shown that FGF-acidic is highly regulated and it is a direct angiogenesis factor. If unregulated angiogenesis could contribute to several diseases including arthritis diabetes ocular neovascularization and especially tumors. Therefore FGF-acidic is treated as a potential oncogene and its overexpression is correlated tightly with several cancers.
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