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MP Biomedicals™ Fibrinogen

Catalog No. MP215416525 Shop All MP Biomedicals, Inc Products
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MP215416525 25 g
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Description

Converted to fibrin by thrombin. Fibrinogen, MP Biomedicals a is a blood protein that is involved in clotting. It consists of three non-identical pairs of disulfide bonded chains. Fibrinogen has been used in studies of haemostatic therapy in trauma patien

Fibrinogen has been used in studies of haemostatic therapy in surgical and massive trauma patients. These studies have shown that fibrinogen may prove to be more superior in stopping blood loss when compared to using fresh frozen plasma (FFP).

Fibrinogen is an acute phase protein that is part of the coagulation cascade of proteins. The end result of the cascade is the production of thrombin that converts fibrinogen to fibrin. Fibrinogen from any mammalian source will be cleaved by thrombin from any mammalian source.

  • Thrombin rapidly proteolyzes fibrinogen, releasing fibrinopeptide A
  • The loss of this small peptide is not sufficient to make the resulting fibrin molecule insoluble, but it tends to form complexes with adjacent fibrin and fibrinogen molecules
  • Thrombin then cleaves a second peptide, fibrinopeptide B, from fibrin and the fibrin monomers formed then polymerize spontaneously to form an insoluble gel
  • The polymerized fibrin is held together by noncovalent and electrostatic forces and stabilized by the transamidating enzyme, factor XIIIa, that is produced by the action of thrombin on factor XIII
  • The insoluble fibrin aggregates (clots) and aggregated platelets then block the damaged blood vessel and prevent further bleeding
  • The amount of fibrinogen in the plasma can serve as a nonspecific indicator of whether or not an inflammatory process is present in the body
TRUSTED_SUSTAINABILITY

Chemical Identifiers

Synonym Factor I

Specifications

Quantity 25 g
Content And Storage −20°C
Form Powder
Solubility Soluble in DI H2O (4% w/v).

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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