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Apexbio Technology LLC Fidaxomicin 873857-62-6 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B17555.1
Fidaxomicin is a macrocyclic antibiotic derived from Actinomycetes functioning through inhibition of bacterial RNA polymerase by targeting the -subunit thereby interfering with bacterial RNA synthesis It exhibits specific antibacterial effects against Clostridium difficile suppressing toxin production and reducing disease recurrence in Clostridium difficile infections (CDI) Fidaxomicin has entered phase III clinical investigation for treatment of CDI Experimental results indicate an intravenous LD50 of approximately 200 mg/kg in rats reported inhibitory concentrations (IC50) against C difficile RNA polymerase range in the nanomolar scale It is utilized in research for studying bacterial transcription mechanisms and evaluating treatment strategies aimed at CDI
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