Medchemexpress LLC Filanesib | 885060-09-3 | C20H22F2N4O2S | 100 MG

Supplier:  Medchemexpress LLC HY15187100MG

Filanesib is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor with an IC50 of 6 nM for human KSP. It induces cell death by apoptosis in vitro and has potent anti-proliferative activity.

• Induces mitotic arrest in multiple cell lines.
• Exhibits anti-proliferative activity against a broad range of human and rodent tumor cell lines.
• Induces apoptosis in a dose-dependent manner in HeLa cells.
• Causes accumulation of cells in the G2/M phase of the cell cycle in HeLa cells.
• Potently induces cell cycle block and subsequent death in leukemic cells via the mitochondrial pathway.
• Able to induce caspase-2 activation.
• Cytotoxic in Type II EOC cells.
• Demonstrates anti-tumor activity in vivo.

Catalog No. 50-003-72290