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Medchemexpress LLC Filgotinib (maleate) | 1802998-75-9 | 99.88% | 541.58 | 100 MG
Supplier: Medchemexpress LLC HY18300A100MG
Filgotinib maleate is a selective, orally available JAK1 inhibitor with anti-inflammatory and antiviral activities. It inhibits the activities of JAK1, JAK2, JAK3, and TYK2. It also inhibits HIV-1 driven gene transcription and reduces the proliferation of HIV-1 infected cells. It is used in the study of rheumatoid arthritis and inflammatory bowel disease.
- Selectively inhibits JAK1 with high potency
- Demonstrates anti-inflammatory and antiviral properties
- Inhibits Th2 and Th1 cell differentiation in a dose-dependent manner
- Produces dose-dependent bone damage protection in rat models of collagen-induced arthritis
- Reduces inflammatory cell infiltration and protects articular cartilage and bone
- Reduces serum levels of inflammatory cytokines and chemokines
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