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Medchemexpress LLC Filgotinib maleate | 1802998-75-9 | 99.88% | 541.58 | 25 MG
Supplier: Medchemexpress LLC 25MGHY18300A
Filgotinib maleate (GLPG0634 maleate) is a selective, orally available JAK1 inhibitor with anti-inflammatory and antiviral activities. It effectively inhibits the activities of JAK1, JAK2, JAK3, and TYK2 with IC50 values of 10 nM, 28 nM, 810 nM, and 116 nM, respectively. It also inhibits HIV-1 driven gene transcription and reduces the proliferation of HIV-1 infected cells. It can be used in the study of rheumatoid arthritis and inflammatory bowel disease.
- Selective, orally available JAK1 inhibitor
- Exhibits anti-inflammatory activities
- Demonstrates antiviral activities
- Inhibits HIV-1 driven gene transcription
- Reduces proliferation of HIV-1 infected cells
- Potential for use in rheumatoid arthritis research
- Potential for use in inflammatory bowel disease research
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