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Medchemexpress LLC Fingolimod hydrochloride | 162359-56-0 | 99.9% | 343.93 | 1 G
Supplier: Medchemexpress LLC 1GHY12005
Fingolimod hydrochloride, also known as FTY720, is a potent sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. It acts as a pak1 activator and an immunosuppressant.
- Reverses the inhibitory effect of S1P on natural killer cell-mediated lysis of K562 tumor cells and dendritic cells.
- Enhances serum S1P levels by inhibiting S1P lyase activity.
- Attenuates microgliosis, modulating the microglia inflammatory phenotype.
- Possesses direct neuroprotective and anti-inflammatory properties.
- Can potentially switch microglia phenotype from detrimental to protective.
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