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Medchemexpress LLC Firibastat (QGC001) | 648927-86-0 | 98.0% | 368.51 | 1 MG
SDP

Catalog No. 5000344747
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Firibastat (QGC001), an orally active brain penetrating proagent of EC33, is a first-in-class brain aminopeptidase A (APA) inhibitor with a Ki of 200 nM. It selectively and specifically inhibits the conversion of brain angiotensin-II into angiotensin-III and decreases blood pressure in hypertensive rats.

  • Orally active and brain penetrating.
  • Functions as a proagent.
  • First-in-class brain aminopeptidase A (APA) inhibitor.
  • Selectively inhibits conversion of brain angiotensin-II into angiotensin-III.
  • Decreases blood pressure in hypertensive rats.
  • Crosses gastrointestinal and blood-brain barriers.
  • Generates two active molecules that inhibit brain APA activity.
  • Blocks brain angiotensin III formation.

Catalog No. 50-003-44747 Supplier Medchemexpress LLC Supplier No. HY10905810MG
May include imposed supplier surcharges.
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Firibastat (QGC001), an orally active brain penetrating proagent of EC33, is a first-in-class brain aminopeptidase A (APA) inhibitor with a Ki of 200 nM. It selectively and specifically inhibits the conversion of brain angiotensin-II into angiotensin-III and decreases blood pressure in hypertensive rats.

  • Orally active and brain penetrating.
  • Functions as a proagent.
  • First-in-class brain aminopeptidase A (APA) inhibitor.
  • Selectively inhibits conversion of brain angiotensin-II into angiotensin-III.
  • Decreases blood pressure in hypertensive rats.
  • Crosses gastrointestinal and blood-brain barriers.
  • Generates two active molecules that inhibit brain APA activity.
  • Blocks brain angiotensin III formation.

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