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STEMCELL Technologies FK506, Size: 50 mg
Supplier: STEMCELL Technologies 74154
FK506 is a macrolide antibiotic with potent immunosuppressive properties (Thomson et al.). It inhibits the calcineurin/NFAT pathway (Martinez-Martinez & Redondo) and binds with high affinity to FK506 binding protein 12 (FKBP-12) (Thomson et al.).MAINTENANCE AND SELF-RENEWAL· Promotes the self-renewal of mouse embryonic stem cells independent of leukemia inhibitory factor (LIF), and attenuates differentiation following LIF withdrawal (Li et al.). · In combination with 1-Azakenpaullone (Catalog #74252) and ID-8 (Catalog #72502), enhances the expansion rates of several human pluripotent stem cell lines (Yasuda et al.).IMMUNOLOGY· Inhibits pro-inflammatory cytokine production by activated T cells (Sakuma et al.).
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